| 摘要 |
A composition for the modification of neoplastic and other cellular process in warm blooded animals or cell cultures is described. The composition contains a membrane impermeable compound to be released selected from the group containing DNA, oligo (deoxy) nucleotides, mRNA, antisense DNA, sugars, proteins, peptides, membrane impermeable drugs, other membrane impermeable molecules, covalently or non-covalently bonded combinations from the above mentioned molecules, gelonin (an antineoplastic compound) and a photosensitizing compound selected from the a group containing porphyrins, phthalocyanines, purpurins, chlorines, benzoporphyrins, napthalocyanines, cationic dyes, tetra cyclones and lysosomotrophic weak bases and derivates thereof. The composition is taken up in endosomes, lysosomes or other cell compartments. Light activation of photosensitizing compound is then used to rupture the membranes of the endosomes, lysosomes or other cell compartments, releasing the molecules into the cytosol of cells.
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