| 摘要 |
<p>To provide compounds which have further excellent antagonisms to NK1 receptor, NK2 receptor and NK3 receptor, have elevated oral absorbability and show favorable kinetics in vivo. [Means for Solution] Compounds represented by general formula (I) or pharmaceutically acceptable salts, ester or other derivatives of the same, wherein R1 represents alkyl; R2 represents optionally substituted 5-membered heteroaryl containing nitrogen or optionally substituted 5-membered heterocyclyl containing nitrogen; R3 represents optionally substituted aryl or optionally substituted heteroaryl; A represents CO or SO¿2?; E represents CH2, O or S; G represents an optionally substituted cycloalkane ring, an optionally substituted cycloalkene ring or an optionally substituted saturated heterocycle; Ar represents an optionally substituted aryl ring or an optionally substituted heteroaryl ring; m is 1 or 2; and n is from 2 to 4.</p> |
