Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof

摘要

The present invention relates to nucleic acid molecules encoding hepatitis C virus, chimeric hepatitis C virus or hepatitis C virus envelope two protein which lacks all or part of hypervariable region one of the envelope two protein. The invention further relates to the use of these nucleic acid molecules and their encoded polypeptides as vaccine candidates.