VIP54 PROTEIN AND RELATED MATERIALS

摘要

"VIP54" protein was identified by yeast two-hybrid screening using H.pylori VacA as bait. VIP54 is not detected in neurons, but is detected in neuroblastoma cells removed from a tumour. Furthermore, VIP54 co-distributes with vimentin and decorates intermediate filaments with a dotted pattern. The invention provides proteins comprising the amino acid sequence of VIP54, as well as related peptides, nucleic acid and antibodies. These are useful as diagnostic reagents for neuroblastoma, as markers for intermediate filaments, and for the inhibition of the VIP54/VacA interaction.