| 摘要 |
<p>New Process for the Preparation of Retiferol Derivatives The invention is concerned with a new process for the preparation of retifer ol derivatives of formula I: wherein A is -C =C- or -CH=CH-, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, by method A) which comprises the coupling of ketones of formula II with compoun ds of formula III or by method B) which comprises the coupling of phosphinoxides of formula IV with aldehydes of formula V Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated wit h photodamage.</p> |
