发明名称 |
Increasing enatioselectivity in reductions with borane reagents |
摘要 |
A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species (for example, a borohydride stabilized borane-tetrahydrofuran complex) catalyzed by a chiral catalyst includes the step of maintaining the concentration of borohydride species in the borane reagent below approximately 0.005 M during the reduction of the prochiral substrate. A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species that is catalyzed by a chiral catalyst includes the step of reducing the detrimental effect the borohydride species has on enantioselectivity by adding a Lewis acid. For example, the prochiral substrate can be a ketone and the chiral catalyst can be a chiral oxazaborolidine.
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申请公布号 |
US6218585(B1) |
申请公布日期 |
2001.04.17 |
申请号 |
US20000553264 |
申请日期 |
2000.04.20 |
申请人 |
MINE SAFETY APPLIANCES COMPANY |
发明人 |
MATOS KARL;CORELLA, II JOSEPH A.;BURKHARDT ELIZABETH R.;NETTLES SHAWN M. |
分类号 |
C07B53/00;C07C29/143;(IPC1-7):C07C27/00 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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