发明名称 |
Site-specific conjugation of glycoproteins |
摘要 |
The present invention describes a site specific conjugation method for glycoproteins wherein a stable dihydrazone bond is formed between the glycoproteins and the glycoproteins retain full activity. Also described is a novel glycoprotein-glycoprotein conjugate of the formulawherein X and Y are glycoproteins modified such that the vicinal hydroxyl groups of the carbohydrate moieties in the glycoproteins have been oxidized to aldehydes which are then reacted with a hydrazide functional group to form a hydrazone bond which is represented in Formula I by "-C=NNH-".
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申请公布号 |
US6218160(B1) |
申请公布日期 |
2001.04.17 |
申请号 |
US19980175785 |
申请日期 |
1998.10.20 |
申请人 |
ROCHE DIAGNOSTICS CORPORATION |
发明人 |
DUAN CHUANMING LARRY |
分类号 |
C07K1/107;C07K19/00;G01N33/533;G01N33/535;G01N33/58;(IPC1-7):C07K1/113;C12N9/96 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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