发明名称 Modulators of protein tyrosine phosphatases (ptpases)
摘要 Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPalpha, LAR and HePTP or the like, wherein n, m, X, Y, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5 </SUB>and R<SUB>6 </SUB>are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
申请公布号 AU6985300(A) 申请公布日期 2001.04.17
申请号 AU20000069853 申请日期 2000.09.11
申请人 NOVO-NORDISK A/S;ONTOGEN CORPORATION 发明人 HENRIK SUNE ANDERSEN;THOMAS KRUSE HANSEN;JESPER LAU;NIELS PETER HUNDAHL MOLLER;OLE HVILSTED OLSEN;FRANK URBAN AXE;YU GE;DANIEL DALE HOLSWORTH;TODD KEVIN JONES;LUKE MILBURN JUDGE;WILIAM CHARLES RIPKA;BARRY ZVI SHAPIRA;ROY TERUYUKI UYEDA
分类号 A61K31/381;A61K31/4035;A61K31/4045;A61K31/407;A61K31/4178;A61K31/423;A61K31/427;A61K31/428;A61K31/433;A61K31/437;A61K31/4433;A61K31/4439;A61K31/4985;A61K31/517;A61K31/538;A61K31/549;A61K31/618;A61P3/00;A61P3/04;A61P3/10;A61P5/00;A61P5/02;A61P5/06;A61P7/00;A61P7/04;A61P17/00;A61P17/06;A61P19/00;A61P19/10;A61P25/00;A61P25/18;A61P25/28;A61P31/00;A61P35/00;A61P37/00;A61P37/02;A61P37/04;A61P37/08;A61P43/00;C07D495/04;C07D519/00 主分类号 A61K31/381
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