发明名称 |
Recombinant microorganisms |
摘要 |
A method of enhancing expression of a desired protein at mucosal effector sites, said method comprising placing the protein to be expressed under the control of a promoter having SEQ ID NO 2. SEQ ID NO 3 or SEQ ID NO 4 or a fragment or variant or any of these which has promoter activity, and causing expression in mucosal cells. Constructs used in the methods, as well as suitable recombinant gut-colonising microorganisms such as a <I>Salmonella spp</I>. are also described and claimed. Such organisms are useful in the preparation of vaccines. |
申请公布号 |
AU7020600(A) |
申请公布日期 |
2001.04.17 |
申请号 |
AU20000070206 |
申请日期 |
2000.09.06 |
申请人 |
THE SECRETARY OF STATE FOR DEFENCE |
发明人 |
RICHARD WILLIAM TITBALL;HELEN LISA BULLIFENT |
分类号 |
C12N15/09;A61K35/66;A61K38/00;A61K39/07;A61K48/00;A61P31/04;C07K14/24;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/74;C12R1/42 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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