发明名称 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO!-1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR
摘要 The present invention relates to novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are surprisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.
申请公布号 WO0125240(A1) 申请公布日期 2001.04.12
申请号 WO2000EP09917 申请日期 2000.10.06
申请人 TIBOTEC NV;THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;WIGERINCK, PIET, TOM, BERT, PAUL;WANG, GUANGYANG;EISSENSTAT, MICHAEL;ERICKSON, JOHN, W. 发明人 WIGERINCK, PIET, TOM, BERT, PAUL;WANG, GUANGYANG;EISSENSTAT, MICHAEL;ERICKSON, JOHN, W.
分类号 A61K31/34;A61K31/36;A61P31/12;A61P31/14;A61P31/18;A61P43/00;C07D493/04;(IPC1-7):C07D493/04 主分类号 A61K31/34
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