SUPPRESSION OF ENDOGENOUS IGFBP-2 TO INHIBIT CANCER

摘要

The present invention concerns the role of IGFBP-2 in cancer. Cancers that are dependent on IGFBP-2 would benefit from therapies targeting IGFBP-2. The invention discloses methods for inhibiting IGFBP-2 dependent cancers by modulating IGFBP-2 activity. Modulation can be achieved by decreasing the amounts of IGFBP-2 protein or IGFBP-2 activity, as well as other polypeptides that interact with or modify IGFBP-2. Preferred modulators of IGFBP-2 include antibodies specific for IGFBP-2 and antisense or ribozymes specific for IGFBP-2 nucleic acid. These modulators are useful for treating cancers derived from any tissue, with cancer of the prostate being preferred. Methods of treating a subject with cancer are disclosed as well as compositions of IGFBP-2 modulators and kits containing such modulators.