PROCESS FOR THE PREPARATION OF PAROXETINE INTERMEDIATE

摘要

Compounds of formula (1) intermediates in the manufacture of paroxetine, are prepared by reacting 4-fluoro- alpha -methyl styrene with benzylamine, or a salt thereof, and formaldehyde in an acidic medium, preferably hydrochloric acid, at elevated temperature, such as 50-100 DEG C. The compound of formula (1) is isolated in crystalline form, as the toluene sulphonic acid salt.