| 发明名称 |
IL13 MUTANTS |
| 摘要 |
This invention provides mutant human interleukin 13 molecules showing varyin g specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13 molecules include those made by substituting the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other ami no acid residues. Some of the mutants retain the ability to bind and cause signaling through IL13 receptors, while other mutants do not.
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| 申请公布号 |
CA2386248(A1) |
申请公布日期 |
2001.04.12 |
| 申请号 |
CA20002386248 |
申请日期 |
2000.10.05 |
| 申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
DEBINSKI, WALDEMAR;THOMPSON, JEFFREY P. |
| 分类号 |
C12N15/09;A61K38/00;A61P11/06;A61P29/00;A61P35/00;A61P37/08;C07K14/01;C07K14/195;C07K14/21;C07K14/54;C07K16/24;C07K19/00;C12N5/06;C12N15/24;(IPC1-7):C07K19/00;A61K38/20 |
主分类号 |
C12N15/09 |
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