发明名称 |
IMPROVED RICIN-LIKE TOXINS FOR TREATMENT OF CANCER |
摘要 |
The present invention provides a protein having chain of a ricin-like toxin, a B chain of a ricin-like toxin and a novel heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a specific protease such as those found in inflammatory cells and cancer cells. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying cells having a specific protease, such as cancer cells or inflammatory cells utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human inflammation and cancer.
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申请公布号 |
WO0125267(A2) |
申请公布日期 |
2001.04.12 |
申请号 |
WO2000CA01162 |
申请日期 |
2000.10.04 |
申请人 |
TWINSTRAND THERAPEUTICS INC.;BRAUN, CURTIS;PURAC, ADMIR;BORGFORD, THOR |
发明人 |
BRAUN, CURTIS;PURAC, ADMIR;BORGFORD, THOR |
分类号 |
A61K38/00;C07K14/415;(IPC1-7):C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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