发明名称 Antisense modulation of bcl-x expression
摘要 Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
申请公布号 US6214986(B1) 申请公布日期 2001.04.10
申请号 US19990323743 申请日期 1999.06.02
申请人 ISIS PHARMACEUTICALS, INC. 发明人 BENNETT C. FRANK;DEAN NICHOLAS M.;MONIA BRETT P.;NICKOLOFF BRIAN J.;ZHANG QINGQING
分类号 C12N15/09;A61K9/10;A61K31/337;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K33/24;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07H21/04;C12N5/10;C12N15/113;C12R1/91;(IPC1-7):C07H21/04;C07H21/02;C12Q1/68;A01N43/04;A61K31/70 主分类号 C12N15/09
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