The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding the ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.
申请公布号
WO0123584(A1)
申请公布日期
2001.04.05
申请号
WO2000US26499
申请日期
2000.09.26
申请人
MILLENNIUM PHARMACEUTICALS, INC.;KAPELLER-LIBERMANN, ROSANA;HUNTER, JOHN, JOSEPH