Methods of Synthesing Purine Compounds Having PDE Iv Inhibitory Activity

摘要

The present invention comprises compounds having the general formula I:wherein:Y, is N or CHZ is selected from the group consisting of alkyl groups such as alkylene groups such as CH2, CH2CH2, CH(CH3); alkenyl groups such as CH=CH; alkynyl groups such as C=C; and NH, N(C1-C3 alkyl), O, S, C(O)CH2 and OCH2;R1 and R2 are selected from the group consisting of hydrogen and a C1-C8 straight or branched alkyl or a C3-C8 cycloalkyl;R3 is a C3-C12 straight or branched alkyl;R4 is a C3-C10 cycloalkyl optionally substituted with OH or C3-C10 cycloalkenyl optionally substituted with OH; andR8 is a C1-C8 straight or branched alkyl or a C3-C8 cycloalkyl, optionally substituted with OH;and methods of synthesis.