发明名称 |
Transgenic mouse expressing a familial form of human amyloid precursor protein |
摘要 |
Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.
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申请公布号 |
US6211428(B1) |
申请公布日期 |
2001.04.03 |
申请号 |
US19970793558 |
申请日期 |
1997.04.28 |
申请人 |
MERCK & CO., INC. |
发明人 |
SINGH GURPARLASH;CHEN HOWARD Y.;HEAVENS ROBERT P.;SIRINATHSINGHJI DALIP J. S.;SMITH DAVID W.;TRUMBAUER MYRNA E.;VAN DER PLOEG LEONARDUS H. T.;VONGS AURAWAN;ZHENG HUI |
分类号 |
A01K67/027;C07K14/47;C12N5/10;C12N15/09;C12N15/85;(IPC1-7):A01K67/00;A01K67/033;G01N33/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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