USE OF REPLICATION-DEFICIENT ADENOVIRAL VECTOR TO BOOST CD8+T CELL IMMUNE RESPONSE TO ANTIGEN

摘要

Use of a replication-deficient adenoviral vector encoding an antigen or a CD 8+ T cell epitope of the antigen to boost in the individual a CD8+ T cell immun e response to the antigen following prior administration of a priming composition. The priming composition comprises the antigen or epitope or nucleic acid encoding the antigen or epitope, and may be DNA, Ty-LVP'S or Modified Virus Ankara (MVA). Administration may be intradermal or intramuscular.