The invention relates to adenoviral vectors comprising a mammalian regulatory region such as a cytokine regulatory region and a reporter gene operatively linked to the cytokine promoter. Preferably, the cytokine promoter is a TNF alpha promoter or an IL-10 promoter. The application also disclosesmethods of studying cytokine promoter activity and to cells containing the adenoviral vectors.
申请公布号
WO0121823(A2)
申请公布日期
2001.03.29
申请号
WO2000GB03645
申请日期
2000.09.22
申请人
THE MATHILDA & TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY;FELDMAN, MARC;FOXWELL, BRIAN, MAURICE, JOHN