发明名称 |
Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines |
摘要 |
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
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申请公布号 |
US6207416(B1) |
申请公布日期 |
2001.03.27 |
申请号 |
US19970809523 |
申请日期 |
1997.05.28 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
TSAREV SERGEI A.;EMERSON SUZANNE U.;PURCELL ROBERT H. |
分类号 |
A61K38/00;A61K39/00;C07H21/00;C07K14/08;C12N7/00;C12N15/113;C12N15/51;(IPC1-7):C12N15/51 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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