A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of the substance.
申请公布号
WO0120283(A1)
申请公布日期
2001.03.22
申请号
WO2000US24992
申请日期
2000.09.12
申请人
UT-BATTELLE, LLC
发明人
DOKTYCZ, MITCHEL, J.;BRITTON, CHARLES, L., JR.;SMITH, STEPHEN, F.;ODEN, PATRICK, I.;BRYAN, W., L.;MOORE, JAMES, A.;THUNDAT, THOMAS, G.;WARMACK, ROBERT, J.