发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS |
摘要 |
Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a target that regulates production of IFN- gamma in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an IL-18 antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In yet another embodiment, the agent is an NK cell antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. In yet another preferred embodiment, the agent is an anti-asialo-GM1 antibody or an NK1.1 antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists. The methods of the invention can be used in the treatment of a variety of inflammatory and immunological diseases and disorders. Pharmaceutical compositions comprising an agent which antagonizes a target that regulates production of IFN- gamma in a subject, a corticosteroid and a pharmaceutically acceptable carrier are also provided. A preferred composition comprises an ICE inhibitor, a corticosteroid and a pharmaceuticaly acceptable carrier.
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申请公布号 |
WO0119373(A2) |
申请公布日期 |
2001.03.22 |
申请号 |
WO2000US24725 |
申请日期 |
2000.09.08 |
申请人 |
BASF AKTIENGESELLSCHAFT;SEKUT, LES;CARTER, ADAM;GHAYUR, TARIQ;BANERJEE, SUBHASHIS;TRACEY, DANIEL, E. |
发明人 |
SEKUT, LES;CARTER, ADAM;GHAYUR, TARIQ;BANERJEE, SUBHASHIS;TRACEY, DANIEL, E. |
分类号 |
A61K31/57;A61K39/395;A61K45/06;C07K16/28;(IPC1-7):A61K31/57 |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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地址 |
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