| 摘要 |
Pleuromultilin beta -ketoesters of Formula (IA) or (IB), in which R<1> is a nitrogen containing heterocycle, an optionally substituted aryl or optionally substituted heteroaryl group, or CH2R<5>; R<2> is vinyl or ethyl; R<3> is H, OH or F; and R<4> is H; or R<3> is H and R<4> is F; in which R<5> is halogen or SR<6>; and R<6> is aminoalkyl, a nitrogen containing heterocycle, or an optionally substituted aryl or optionally substituted heteroaryl groupare of use in therapy as antibacterial agents. |
