| 摘要 |
<p>A method of treating a cell proliferative disorder including types of cancer, causes inhibition of blood supply to the cancerous region, eg., a tumor, by administering an admixture of a predetermined quantity of a polyunsaturated fatty acid in the form of a solution of at least one polyunsaturated fatty acid together with optionally a predetermined anticancer drug, a cytokine and an oily lymphographic agent. In a preferred form, the admixture is injected intra-arterially through a catheter into an artery which provides the major blood supply to the tumor, the artery being proximate to the tumor. The solution of the polyunsaturated fatty acid may comprise an essential fatty acid(s) metabolite in salt form, eg., a lithium salt for non-glioma type of tumor, and a sodium/potassium salt for treating glioma. The polyunsaturated fatty acid content in the admixture may be in the range of 0.5 mg to 50 gm. The cytokine (lymphokine) may be tumor necrosis factor and/or interferon. The admixture may be administered orally or parenterally or by methods which are selective combinations, eg., intra-arterial, oral and parenteral. Examples given of cancers treated include hepatoma, giant cell tumor of the bone and glioma. The invention by cutting off blood supply to the tumor region causes massive necrosis of the cancerous cells, and prevents angiogenic activity in the tumor region.</p> |
