发明名称 |
METHOD FOR TREATING AND PREVENTING BACTERIAL INFECTION |
摘要 |
The present invention provides methods and compositions for treating bacterial infections, especially infections by opportunistic pathogens in a subject by administering a compound that inhibits syndecan-1 shedding. The invention is based on the discovery that two diverse opportunistic pathogens, <i>S. aureus</i> and <i>P. aeruginosa</i>, enhance syndecan-1 shedding and that this shedding is critical for <i>Pseudomonas</i> pathogenesis via the respitory tract. The discovery is also based on the surprising finding that inhibition of syndecan-1 shedding prevents <i>Pseudomonas</i> pneumonia in a mammalian model. The <i>P. aeruginosa</i> shedding enhancer has been purified and identified as the mature 20 kDa LasA protein, a known virulence factor of <i>P. aeruginosa</i>.
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申请公布号 |
WO0117560(A1) |
申请公布日期 |
2001.03.15 |
申请号 |
WO2000US24839 |
申请日期 |
2000.09.11 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;BERNFIELD, MERTON;PARK, PYONG, WOO |
发明人 |
BERNFIELD, MERTON;PARK, PYONG, WOO |
分类号 |
A61K31/00;A61K31/277;A61K31/352;C07K16/28;(IPC1-7):A61K39/395;A61K39/02;A61K39/085;A61K39/108;C12Q1/00;C12Q1/18;C07K1/00;C07K16/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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