摘要 |
The present invention relates to the art of molecular biology and, more specifically, to novel dinucleoside 5',5'-tetraphosphate derivatives which are selective inhibitors of the reproduction of the human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) reproduction, specifically inhibit the action of retrovirus and hepadnavirus reverse transcriptases in cells and cell-free systems, and prevent intact cells from infection. |