发明名称 |
METHOD FOR ENCAPSULATING ACTIVE SUBSTANCES BY COACERVATION OF POLYMERS IN NON-CHLORINATED ORGANIC SOLVENT |
摘要 |
The invention concerns a method for microencapsulation of an active principle by coacervation which consists in controlled desolvation or coacervation of a polymer dissolved in an organic solvent containing said active principle, said coacervation being induced by adding a non-solvent causing the polymer to be deposited at the surface of the active principle, and by hardening the polymer deposit by adding a hardening agent, said hardening being leading to the formation of a continuous film coating the active principle. The invention is characterised in that the solvent is selected among ethyl acetate, N-methylpyrrolidone, methylethylacetone and acetic acid. The non-solvent is advantageously an alcohol comprising two to five carbon atoms and the hardening agent being for instance selected among water, alcohols comprising four carbon atoms and mixtures thereof.
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申请公布号 |
WO0115799(A1) |
申请公布日期 |
2001.03.08 |
申请号 |
WO2000FR02376 |
申请日期 |
2000.08.25 |
申请人 |
MAINELAB;BENOIT, JEAN-PIERRE;RICHARD, JOEL;FOURNIER, ELVIRE;LIU, SONIA |
发明人 |
BENOIT, JEAN-PIERRE;RICHARD, JOEL;FOURNIER, ELVIRE;LIU, SONIA |
分类号 |
B01J13/06;A61K9/16;B01F17/38;B01F17/56;B01J13/08;(IPC1-7):B01J13/08;A61K9/50 |
主分类号 |
B01J13/06 |
代理机构 |
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