SCREENING FOR AGENTS MODULATING TGF-BETA CELL SIGNALING
摘要
Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF- beta ) and members of the TGF- beta family, such as bone morphogenic protein (BMP). Such agents may be identified using screens that evaluate candidate agents for the ability to modulate Smad protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF- beta family members in a variety of cell types and for therapeutic purposes.
申请公布号
WO0116604(A1)
申请公布日期
2001.03.08
申请号
WO2000US23729
申请日期
2000.08.29
申请人
SIGNAL PHARMACEUTICALS, INC.;HOEKSTRA, MERL, F.;XIE, WEILIN;MURRAY, BRION, W.;MERCURIO, FRANK, M.
发明人
HOEKSTRA, MERL, F.;XIE, WEILIN;MURRAY, BRION, W.;MERCURIO, FRANK, M.