| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain a new protein which has a specific amino acid sequence, has an ability of binding an armadillo repeat site of a gene product of a colon carcinoma suppressor gene, can control the colon carcinoma, and is useful for treating and diagnosing the colon tumor and so on. SOLUTION: This is a new colon carcinoma suppressor gene-related protein which is a polypeptide selected from a group comprising a polypeptide having the amino acid sequence shown by the formula, polypeptides containing the amino acid sequence shown by the formula, polypeptides having a homology of about 70% or more to the polypeptide having the amino acid sequence shown by the formula and an ability of binding a polypeptide encoded by the armadillo repeat site of a gene product of a colon carcinoma suppressor gene (Adenomatous Polyposis Coli, APC), and the like, allows the control of APC, and is useful for treating and/or diagnosing the colon carcinoma and so on. This protein is obtained by identifying cDNA of a protein binding an APC gene product from a fetal brain cDNA library for expression.</p> |
