摘要 |
An agent for combatting an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target cell, the phage causes lysis of a microorganism residing within the target cell. A mycobacteriophage is combined with a targeting moiety of transferrin. Compositions comprising the agent, methods of preparing said agent, and use of said agent for combatting intracellular infections are also provided.
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申请人 |
MICROBIOLOGICAL RESEARCH AUTHORITY;PASECHNIK, VLADIMIR, ARTYMOVICH;ROBERTS, ALLEN, DOUGLAS, GLEN;SHARP, RICHARD, JAMES |
发明人 |
PASECHNIK, VLADIMIR, ARTYMOVICH;ROBERTS, ALLEN, DOUGLAS, GLEN;SHARP, RICHARD, JAMES |