发明名称 |
IMPROVED MENINGOCOCCAL POLYSACCHARIDE CONJUGATE VACCINE |
摘要 |
<p>Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.</p> |
申请公布号 |
SI20008(B) |
申请公布日期 |
2001.02.28 |
申请号 |
SI19910010243 |
申请日期 |
1990.12.14 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
JENNINGS HAROLD J.;MICHON FRANCIS |
分类号 |
A61K39/00;A61K38/00;A61K39/02;A61K39/095;A61K39/108;A61K39/385;A61K39/395;A61P31/04;C07K16/12;C08B37/00;C12P19/04;(IPC1-7):A61K39/095 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|