| 发明名称 |
COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS |
| 摘要 |
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner. |
| 申请公布号 |
US2016159849(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201514962742 |
申请日期 |
2015.12.08 |
| 申请人 |
Warsaw Orthopedic, Inc. |
发明人 |
Harrington Roger E.;Jacobs Jerbrena C.;Gopal Damodaragounder;Ling Ke-Qing;Burello Marco |
| 分类号 |
C07J9/00 |
主分类号 |
C07J9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of making an oxysterol, the method comprising reacting a diol having the formula: with a borane compound to form the oxysterol or a pharmaceutically acceptable salt, hydrate or solvate thereof having the formula: wherein R1 comprises an aliphatic or cyclic substituent having at least one carbon atom, and R2 comprises an aliphatic or cyclic substituent having at least one carbon atom. |
| 地址 |
Warsaw IN US |
