| 摘要 |
The invention relates to a labelled peptide compound, wherein the peptide has a selective neurotensin receptor affinity and is represented by the general formulawherein:R1 is a (C1-C3)alkanoyl group, an arylcarbonyl group, an aryl-(C1-C3)alkanoyl group, or a chelating group attached by an amide bond or through a spacing group to the peptide molecule;Xaa and Xbb are each individually Arg or Lys;Xcc is an unsubstituted or substituted cyclic amino acid, preferably selected from Pro and Hyp;Xdd is Tyr, Trp or Phe;Xee is Leu, Ile or t.-butylalanine; andn is 0 or 1;and wherein said peptide is labelled with (a) a metal isotope, or(b) with a radioactive halogen isotope; on the understanding that:(i) if the label is a metal isotope, R1 represents a chelating group for chelating said isotope; and(ii) if the label is a radioactive halogen isotope, said halogen isotope is attached to 4Tyr in the 2-position of the phenyl ring, to 4Trp, or to the aryl group of substituent R1.The invention further relates to a pharmaceutical composition comprising said labelled peptide compound, to the use of said composition for diagnosis and therapy, and to a kit for preparing a radiopharmaceutical composition.
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