METHODS FOR IDENTIFICATION OF COMPOUNDS STIMULATING INSULIN SECRETION

摘要

According to the invention .beta.-tubulin, as well as a 65 kDa polypeptide present in pancreatic .beta.-cells, have been identified as molecular target s for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, said compounds thereby stimulating insulin secretion.