| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound having a ketone group and an ester group, and useful as a reaction raw material, etc. for synthesizing various functional materials such as a chiral host compound, etc. SOLUTION: This oxo ester compound is s compound of formula I (R1, R2 are each an aliphatic, aromatic or heterocyclic group). The compound of the formula I is obtained by reacting (A) a lower alkylsulfinyl methyl ketone of formula II (R4 is a lower alkyl) or (B) a lower alkylthioacetal compound of formula III (R3 is H, or an aliphatic, aromatic or heterocyclic group) with (C) a hydroxyl compound of the formula: R2OH (e.g. methanol, t-butanol) in the presence of (D) a copper salt, preferably anhydrous cupric chloride, cupric bromide, copper sulfate, etc., in an organic solvent (e.g. acetonitrile, acetone) at 50-120 deg.C. In the above reaction, it is preferable to set 1-8 in the amount of the component D and 1-7 of the component C based on 1 using amount of the component A or B in molar ratio. |
