PERIODIC STRUCTURES COMPRISING LIPIDS, POLYELECTROLYTES, AND STRUCTURE-INDUCING SOLUBLE OLIGOVALENT LINKERS, AND BIOLOGICAL USE THEREOF

摘要

This invention describes a method for preparing pharmaceutically usable compositions comprising periodic structures consisting of polyelectrolytes sandwiched between lipid aggregates having at least one charged component which is characterised in that a suspension of non-periodic, preferably mono- or bilayer like, lipid aggregates, a solution of polyelectrolyte molecules, and a solution of oligovalent linkers are separately made and then mixed to form said periodic structures, the simultaneous presence of said components catalysing the formation of controlling the rate of formation of said periodic structures comprising at least one layer of lipid component associated with a layer of polyelectrolyte molecules.