Difficulties arising when spray drying paroxetine hydrochloride from water-containing solutions are overcome by keeping the outlet gas temperature in the range 40-55 DEG C, and the water content of the outlet gas below 1.1 kg per 100 kg of outlet gas. The feedstock may be a water-containing solution or suspension of excipient(s) in the range 20-60 % by wt. and paroxetine hydrochloride in the range 1-10 % by wt., in which case the outlet gas temperature is in the range 40-75 DEG C.
