DIFFERENCE DETECTION METHODS USING MATCHED MULTIPLE DYES

摘要

Proteins that are differentially expressed in body weight and eating disorders, such as obesity, are identified. Agents to treat such conditions may be identified by a screening method comprising: a) establishing a paradi gm in which at least one protein is differentially expressed in relevant tissue from, or representative of, subjects having different levels of body weight or eating dysfunction; b) obtaining a sample of relevant tissue taken from, or representative of, a subject having body weight or eating disorders, who or which has been treated with the agent being screened; c) determining the presence, absence or degree of expression of the differentially expressed protein(s); and d) selecting or rejecting the agent according to the extend to which it changes the expression of the differentially expressed protein(s).< /SDOAB>