摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound excellent in oral absorbability and capable of improving diseases including those caused by insulin resistance such as hyperglycemia, glucose tolerance insufficiency, diabetic complication, hyperlipemia, pregnancy diabetes and polycystic ovary syndrome. SOLUTION: This new compound is a 5-[4-(6-methoxy-1-methyl-1H- bennzimidazole-2-ylmethoxy)benzyl]thiazolidine-2,4-dione hydrochloride. The compound is obtained, for example, through the following steps: mixing 5-[4-(6- methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-d ione of the formula which is obtained by using 5-methoxy-N-methyl-1,2- phenylenediamine, a 5-(4-methoxycarbonylmethoxybenzyl)thiazolidine-2,4-dione, 1,4-dioxane and concentrated hydrochloric acid as starting substances, and is a free substance of this compound, with 1,4-dioxane hydrochloride followed by condensation; and then adding ethyl acetate to the thus obtained product.
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