发明名称 |
Melanoma cell lines expressing shared immunodominant melanoma antigens and methods of using same |
摘要 |
The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a cytokine relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogeneic and is not MHC-matched to the host.
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申请公布号 |
US6187306(B1) |
申请公布日期 |
2001.02.13 |
申请号 |
US19970906029 |
申请日期 |
1997.08.05 |
申请人 |
THE JOHNS HOPKINS UNIVERSTIY;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PARDOLL DREW M.;JAFFEE ELIZABETH;ADLER ADAM;TOPALIAN SUZANNE L.;ROSENBERG STEVEN A. |
分类号 |
A61K48/00;A61K35/12;A61K39/00;A61P35/00;(IPC1-7):A61K48/00;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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