DNA REPLICATION PROTEINS OF GRAM POSITIVE BACTERIA AND THEIR USE TO SCREEN FOR CHEMICAL INHIBITORS

摘要

The present invention relates to alpha-large, alpha-small, delta, delta prime, tau, beta, SSB, DnaG DnaB encoding genes from Gram positive bacterium, preferably Streptococcus and Staphylococcus bacterium. The formation of functional polymerase as well as the use of such a polymerase in sequencing and amplification is also disclosed. The individual genes and proteins or polypeptides are useful in identification of compounds with antibiotic activity.