| 摘要 |
<p>Attempts are made to screen clones having kinase/phosphatase-like structures from clones which have been isolated and determined in structure by Helix Research Institute (Helix Clones; Japanese Patent Application 2000-183767). By subjecting all of the helix clones to homology examination with the use of known kinase/phosphatase amino acid sequences as queries, 2 novel genes are obtained. It is expected that these genes participate in signal transduction in cells. The physiological functions of these genes can be searched by using a reporter gene assay system whereby signal transduction can be detected. These proteins are useful as target molecules in designing drugs for the development of novel drugs.</p> |
