ENHANCED DELIVERY OF NUCLEIC ACID-BASED DRUGS

摘要

The invention provides methods and associated compositions for enhancing the intracellular delivery of a nucleic acid-based drug, such as an oligonucleotide or gene, by administering the nucleic acid-based drug in combination or sequentially with an enhancer. Preferred enhancers are caprylic acid, capric acid or their pharmaceutically acceptable salts. The preferred route of administration is oral.