发明名称 |
PYRUVATE CARBOXYLASE OVEREXPRESSION FOR ENHANCED PRODUCTION OF OXALOACETATE-DERIVED BIOCHEMICALS IN MICROBIAL CELLS |
摘要 |
Metabolic engineering is used to increase the carbon flow toward oxaloacetate to enhance production of bulk biochemicals, such as lysine and succinate, in bacterial fermentations. Carbon flow is redirected by genetically engineering the cells to overexpress the enzyme pyruvate carboxylase. |
申请公布号 |
EP1073722(A1) |
申请公布日期 |
2001.02.07 |
申请号 |
EP19990917435 |
申请日期 |
1999.04.13 |
申请人 |
THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
GOKARN, RAVI, R.;EITEMAN, MARK, A.;ALTMAN, ELLIOT |
分类号 |
C12N15/09;C12N1/21;C12N9/00;C12N9/04;C12N9/88;C12N15/01;C12P7/46;C12P13/04;C12P13/08;C12R1/15;C12R1/41 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|