| 发明名称 |
SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE |
| 摘要 |
Novel compounds of the formula (I) which are useful for treating or preventi ng inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-( 4- bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl )- 1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5- dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5- dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and 3-(4- bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
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| 申请公布号 |
CA2378369(A1) |
申请公布日期 |
2001.02.01 |
| 申请号 |
CA20002378369 |
申请日期 |
2000.06.28 |
| 申请人 |
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. |
发明人 |
WU, JIANG-PING;WARD, YANCEY DAVID;KUZMICH, DANIEL;KELLY, TERENCE ALFRED;FRYE, LEAH LYNN |
| 分类号 |
A61K31/404;A61K31/437;A61P1/04;A61P3/10;A61P5/14;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P37/00;A61P37/06;A61P43/00;C07D209/34;C07D471/04;(IPC1-7):C07D487/04;C07D475/00;A61K31/498;A61K31/517;A61K31/53;A61K31/539 |
主分类号 |
A61K31/404 |
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