发明名称 |
CD8 antagonists |
摘要 |
Compounds that inhibit CD8 mediated T cell activation and that have a molecular surface that corresponds to the molecular surface of human CD8 at amino acids 38-46 and/or 53-56 and/or 60-67 and pharmaceutical compositions comprising such compounds are disclosed. Methods of inhibiting activation of a human T cell are disclosed. The methods comprise contacting a T cell with a compound that inhibits CD8 mediated T cell activation and that has a molecular surface that corresponds to the molecular surface of human CD8 at amino acids 38-46 and/or 53-56 and/or 60-67. Methods of treating an individual suspected of suffering from or susceptible to graft versus host disease and/or organ rejection are disclosed. The methods comprise administering an effective amount of a compound that inhibits CD8 mediated T cell activation and that has a molecular surface that corresponds to the molecular surface of human CD8 at amino acids 34-46 and/or 53-56 and/or 60-67.
|
申请公布号 |
US6180600(B1) |
申请公布日期 |
2001.01.30 |
申请号 |
US19970875309 |
申请日期 |
1997.11.26 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
JAMESON BRADFORD A.;CHOKSI SWATI;KORNGOLD ROBERT;HUANG ZIWEI |
分类号 |
A61K38/00;C07K5/103;C07K14/705;C07K14/725;(IPC1-7):A61K38/07;A61K38/08;A61K38/10;A61K38/12 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|