| 发明名称 |
Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression |
| 摘要 |
Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-alpha-converting enzyme (TACE). Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred. Methods of using these oligonucleotides for inhibition of TACE expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TACE or TNF-alpha are provided.
|
| 申请公布号 |
US6180403(B1) |
申请公布日期 |
2001.01.30 |
| 申请号 |
US19990429093 |
申请日期 |
1999.10.28 |
| 申请人 |
ISIS PHARMACEUTICALS INC. |
发明人 |
FLOURNOY SHIN CHENG;BENNETT C. FRANK |
| 分类号 |
C12N15/09;A61K9/10;A61K31/7088;A61K31/7115;A61K31/712;A61K38/00;A61K48/00;A61P1/00;A61P1/16;A61P1/18;A61P3/10;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/02;A61P43/00;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/04;C12N15/113;C12Q1/02;C12Q1/68;(IPC1-7):C07H21/04;C12N15/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
