摘要 |
<p>A method of crystallizing a 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydr opyridine hydrochloride (SR 57746 A), the various crystalline forms obtained and pharmaceutical compositions containing them are described. The crystallization method comprises: (a) dissolving said compound by heating in a solvent selected from alkanols having 1 to 3 carbon atoms, ketones having 3 to 6 carbon atoms, dimethyl sulfoxide and ethyl acetate, said solvent optionally containing from 5 to 30% of water or aqueous hydrochloric acid, (b) cooling the resulting solution to -10/+10 C at a rate of 3 to 100 C/hour, with stirring at 0 to 600 rpm and (c) isolating and optionally micronizing the resulting product.</p> |