NOVEL ANTIVIRUS 2,4-PYRIMIDINEDIONE DERIVATIVES

摘要

PURPOSE: Provided are 2,4-pyrimidinedione derivatives which are excellent in selectivity and bioactivity for wild type and mutant HIV-1 and have low toxicity, therefore which can be used for treating AIDS. CONSTITUTION: The 2,4-pyrimidinedione derivatives represented by the formula I are prepared by coupling two compounds represented by the formulas II and III, wherein R1 is phenyl, pyridyl, methyl, amino, nitro, methoxy, trifluoromethyl, and etc., R2 is ethyl, isopropyl, etc., R3 and R4 is independently hydrogen, fluorine, chlorine, methyl, fluoromethyl, nitro, etc., A is oxygen or sulfur, Z is oxygen, sulfur, C=O, NH, or CH2, Z' is equal to the Z but Z' is acetamido if A is oxygen, Y is halogen, methane sulfonyl, toluene sulfonyl, or trifluoromethane sulfonyl.